Mouse Gene Unc93b1 (ENSMUST00000162708.6) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default) (2024)

Mouse Gene Unc93b1 (ENSMUST00000162708.6) from GENCODE VM23 Comprehensive Transcript Set (only Basic displayed by default)

Description: Mus musculus unc-93 hom*olog B1, TLR signaling regulator (Unc93b1), transcript variant 1, mRNA. (from RefSeq NM_019449)
Gencode Transcript: ENSMUST00000162708.6
Gencode Gene: ENSMUSG00000036908.17
Transcript (Including UTRs)
Position:mm10 chr19:3,935,186-3,949,340Size:14,155Total Exon Count:11Strand:+
Coding Region
Position:mm10 chr19:3,935,194-3,948,942Size:13,749Coding Exon Count:11

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	RNA Structure
Protein Structure	Other Species	GO Annotations	mRNA Descriptions	Pathways	Other Names
Model Information	Methods

Data last updated at UCSC:2019-09-19

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:3,935,186-3,949,340)			mRNA (may differ from genome)		Protein (619 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	MGI
PubMed	Reactome	SOURCE	UniProtKB	Wikipedia

Comments and Description Text from UniProtKB


	ID: E9PYK0_MOUSE DESCRIPTION: SubName: Full=Protein unc-93 homolog B1; CAUTION:* The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

Primer design for this transcript


	Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Click here to load the transcript sequence and exon structure into Primer3Plus Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. Click here to open Exonprimer with this transcript To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749Tetrachlorodibenzodioxin D000082Acetaminophen D002994Clofibrate D003993Dibutyl Phthalate D004041Dietary Fats D006997Hypochlorous Acid D009532Nickel D012999Soman D014635Valproic Acid D014640Vancomycin C400082bortezomib C008261lead acetate C028007nickel monoxide C041786palm oil C006253pirinixic acid C012589trichostatin A C025643vinclozolin

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-104.60	398	-0.263	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR010291 - Ion_channel_UNC-93

Pfam Domains:
PF05978 - Ion channel regulatory protein UNC-93

ModBase Predicted Comparative 3D Structure on E9PYK0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Human	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
Genome Browser	Genome Browser	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details
Gene Sorter
GenBank	RGD	Ensembl
Protein Sequence	Protein Sequence
Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0034138 toll-like receptor 3 signaling pathway GO:0034154 toll-like receptor 7 signaling pathway GO:0034162 toll-like receptor 9 signaling pathway Cellular Component: GO:0005768 endosome GO:0005783 endoplasmic reticulum GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	BC018388 - Mus musculus unc-93 homolog B1 (C. elegans), mRNA (cDNA clone MGC:25627 IMAGE:4209296), complete cds. AK039526 - Mus musculus adult male spinal cord cDNA, RIKEN full-length enriched library, clone:A330055C13 product:unc-93 homolog B (C. elegans), full insert sequence. AK030488 - Mus musculus adult male pituitary gland cDNA, RIKEN full-length enriched library, clone:5330418K19 product:UNC-93 RELATED PROTEIN (FRAGMENT) homolog [Mus musculus], full insert sequence. AK165060 - Mus musculus 2 days pregnant adult female oviduct cDNA, RIKEN full-length enriched library, clone:E230029A13 product:unc-93 homolog B (C. elegans), full insert sequence. AK155556 - Mus musculus NOD-derived CD11c +ve dendritic cells cDNA, RIKEN full-length enriched library, clone:F630323L01 product:unc-93 homolog B (C. elegans), full insert sequence. AK162535 - Mus musculus adult male urinary bladder cDNA, RIKEN full-length enriched library, clone:9530090P06 product:unc-93 homolog B (C. elegans), full insert sequence. AJ422144 - Mus musculus partial mRNA for UNC-93B protein (unc-93B gene). U89424 - Mus musculus strain BALB/c unc-93 related protein mRNA, partial cds. BC025587 - Mus musculus unc-93 homolog B1 (C. elegans), mRNA (cDNA clone IMAGE:5324818), complete cds. AK160499 - Mus musculus adult male tongue cDNA, RIKEN full-length enriched library, clone:2310004D13 product:unc-93 homolog B (C. elegans), full insert sequence. BC023731 - Mus musculus unc-93 hom*olog B1 (C. elegans), mRNA (cDNA clone MGC:38492 IMAGE:5352340), complete cds.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein E9PYK0 (Reactome details) participates in the following event(s): R-MMU-1678921 Full-length TLR3/7/8/9 binds to UNC93B1 R-MMU-1679131 Trafficking and processing of endosomal TLR R-MMU-168898 Toll-Like Receptors Cascades R-MMU-168249 Innate Immune System R-MMU-168256 Immune System

Reactome (by CSHL, EBI, and GO)

Protein E9PYK0 (Reactome details) participates in the following event(s):

R-MMU-1678921 Full-length TLR3/7/8/9 binds to UNC93B1
R-MMU-1679131 Trafficking and processing of endosomal TLR
R-MMU-168898 Toll-Like Receptors Cascades
R-MMU-168249 Innate Immune System
R-MMU-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: E9PYK0, E9PYK0_MOUSE, NM_019449, uc008fxs.1, uc008fxs.2 UCSC ID: uc008fxs.2 RefSeq Accession: NM_019449 Protein: E9PYK0CCDS: CCDS29404.2

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.